Domilise's Po-Boy & Bar

Located in the heart of New Orleans at 5240 Annunciation Street, Domilise's Po-Boy & Bar is an iconic restaurant that perfectly embodies the city's rich culinary heritage. Specializing in classic New Orleans po’boys, this beloved local establishment serves up some of the most mouthwatering sandwiches you’ll find anywhere, celebrated by food legends such as Anthony Bourdain and Emeril Lagasse, and honored with a Michelin Bib Gourmand.

The moment you step inside Domilise’s, you're greeted by an inviting, no-frills atmosphere that echoes the soulful, down-to-earth vibe of old New Orleans. The space is cozy and unpretentious, making it the perfect backdrop for truly savoring the star of the show — their po’boys.

The menu is a treasure trove of New Orleans favorites. The Shrimp Po’Boy is a standout: crispy, golden shrimp nestled in their famously airy yet sturdy po’boy bread, dressed just right with lettuce, tomato, and a tangy remoulade that dances on your palate. For meat lovers, the Roast Beef Po’Boy and the sumptuous Surf & Turf — a generously loaded combination of roast beef and fried shrimp — offer hearty, deeply satisfying flavors that feel like a warm embrace. The seafood options like the Fried Oyster Po’Boy and Half & Half Seafood Po’Boy showcase the bounty of the Gulf, prepared with an expert hand and served in large, share-worthy portions.

What truly elevates the Domilise’s experience is the perfect balance between crunchy and tender textures, the robust seasoning in every bite, and the authentic freshness of their ingredients. Add a side of their golden, crispy French Fries or the uniquely addicting Boo Fries, paired with an ice-cold beer or a spicy, savory Bloody Mary, and you’ve crafted a meal that is unapologetically indulgent and utterly satisfying.

Beyond the food, visitors consistently praise Domilise’s warm hospitality and rich history. Longtime patron Becky Zackaroff perfectly captured the spirit, describing it as “small and quaint” with a “great atmosphere” where everyone feels genuinely friendly. Cassio Costa Santos reflected on the sense of tradition, noting the deep cultural roots and the fact that even former presidents have enjoyed these legendary sandwiches. Brad R’s glowing endorsement highlights how Domilise’s has become a “true New Orleans staple” and a “must-visit” for both locals and tourists alike.

Whether you’re a first-timer exploring the vibrant cityscape of New Orleans or a return visitor craving authentic flavor, Domilise’s Po-Boy & Bar offers an unforgettable dining experience. It’s not just a meal — it’s a heartfelt slice of New Orleans history served fresh on po’boy bread.